ZILOS-tk and LYKOS Articles

Below is a tabbed list of ZILOS-tk and LYKOS publications. If you would like a copy of any of the articles listed as "Available", please email webmaster [AT] hamiltonthorne [DOT] com. You may also download a PDF file of publication list.

You may also browse and search the collection of ZILOS-tk/LYKOS articles on the Pubmed website.

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ZILOS-tk & LYKOS Publications by Year

Available? Reference
No Burrill D, Vernet A, Collins J, Silver PA, Way JC. Targeted erythropoietin selectively stimulates red blood cell expansion in vivo. PNAS; 113(19): 5245-5250.
 Yes Elhoussieny A, El Mandooh M., Bahaa-Eldin A., Fathy H. Laser Assisted Zona Thinning Versus the Conventional Mechanical Method for Intracytoplasmic Sperm Injection in ICSI Programs. International Journal of Obstetrics and Gynaecology Research (IJOGR)2016. 3(2):221-239. Open Access Article
Yes Hu Y, Trolice M. Live birth of twins derived from zona-free oocytes. Fertility and Sterility.2016 Feb. 6; 105 (2): 247-544.
Yes Jing S, Luo K, He H, Lu C, Zhang S, Tan Y, Gong F, Lu G, Lin G. Obstetric and neonatal outcomes in blastocyst-stage biopsy with frozen embryo transfer and cleavage-stage biopsy with fresh embryo transfer after preimplantation genetic diagnosis/screening. Fertility and Sterility. 2016 March 19: 1-12. doi:http://dx.doi.org/10.1016/j.fertnstert.2016.03.010.
Yes Kang HJ, Melnick AP, Stewart JD, Xu K, Rosenwaks Z. Preimplantation genetic screening:who benefits? Fertility and Sterility. 2016 April 30: 1-16. doi:10.1016/j.fertnstert.2016.04.027.
Yes Lin D, Ran J, Chen C, Luo Z, Quan S, Ye B, Yu A, Kang Y, Lin Y. Frozen two day 3 embryos and subsequently produced blastocysts by vitrification: advantages for IVF/ICSI patients at high risk of ovarian hyperstimulation syndrome. IJCEM; 9(3): 6986-6999. Open Access Article
Yes Liu M, Su Y, Wang WH. Assessment of clinical application of preimplantation genetic screening on cryopreserved human blastocysts. Reproductive Bio and Endocrinology. 2016 April 8; 14(16):1-7. doi: 10.1186/s12958-016-0155-z. Open Access Article
Yes Otsuki J, Iwasaki T, Katada Y, Sato H, Furuhashi K, Tsuji Y, Matsumoto Y, Shiotani. Grade and looseness of the inner cell mass may lead to the development of monochorionic diamniotic twins. Fertility and Sterility. 2016 June 2: 1-5.
Yes Ou J, Wang W, Feng T, Liao L, Meng Q, Zou Q, Ding J, Zheng A, Duan C, Li P, Liu Q, Lin C, Li H. Identification of small segmental translocations in patients with repeated implantation failure and recurrent miscarriage using next generation sequencing after in vitro fertilization/intracytoplasmic sperm injection. Mol Cytogenet. 2015 Dec 30;8:105. doi: 10.1186/s13039-015-0207-7. eCollection 2015. PubMed PMID: 26719770; PubMed Central PMCID: PMC4696251. Open Access Article
Yes Richter KS, Ginsburg DK, Shipley SK, Lim J, Tucker MJ, Graham JR, Levy MJ. Factors associated with birth outcomes from cryopreserved blastocysts: experience from 4,597 autologous transfers of 7,597 cryopreserved blastocysts. Fertility and Sterility. 2016 May 9:1-8.
 No Rodriguez-Purata J, Lee J, Whitehouse M, Duke M, Grunfeld L, Sandler B, Copperman A, Mukherjee T. Reproductive outcome is optimized by genomic embryo screening, vitrification, and subsequent transfer into a prepared synchronous endometrium. J Assist Reprod Genet. 2016 Jan 14. [Epub ahead of print] PubMed PMID: 26768140
No Shu Y, Prokai D, Berga S, Taylor R, Johnston-MacAnanny E. Transfer of IVF-contaminated blastocysts with removal of the zona pellucida resulted in live births. Jrnl of Assisted Reproduction and Genetics. 27 July 2016: 1-4. doi: 10.1007/s10815-016-0776-3.
No Tomita K, Sakai S, Khanmohammadi M, Yamochi T, Hasimoto S, Anzai M, Morimoto Y, Taya M, Hosoi Y. Cryopreservation of a small number of human sperm using enzymatically fabricated, hollow hyaluronan microcapsules handled by conventional ICSI procedures. 2016 April; 33(4): 501-511.
Yes Yao G, Xu J, Xin Z, Niu W, Shi S, Jin H, Song W, Wang E, Yang Q, Chen L, Sun Y.  Developmental potential of clinically discarded human embryos and associated chromosomal analysis. Scienific Reports; 6(23995): 1-9. doi: 10.1038/srep23995. Open Access Article
Yes Zhang S, Luo K, Cheng D, Tan Y, Lu C, He H, Gu Y, Lu G, Gong F, Lin G. Number of biopsied trophectoderm cells is likely to affect the implantation potential of blastocysts with poor trophectoderm quality. Fertility and Sterility. 2016 Jan 25: 1-10. doi:http://dx.doi.org/10.1016/j.fertnstert.2016.01.011.
Yes Zhu H, Behr B, Reddy V, Hughes M, Yuqiong P, Baker J. Human Embryonic Stem Cell Lines with Lesions in FOXP3 and NF1. Plos One. 2016 March 18. doi:10.1371/journal.pone.0151836. Open Access Article.

Available? Reference
Yes

Deleye L, Dheedene A, De Coninck D, Sante T, Christodoulou C, Heindryckx B, Van den Abbeel E, De Sutter P, Deforce D, Menten B, Van Nieuwerburgh F. Shallow whole genome sequencing is well suited for the detection of chromosomal aberrations in human blastocysts. Fertil Steril. 2015 Nov;104(5):1276-1285.e1. doi: 10.1016/j.fertnstert.2015.07.1144. Epub 2015 Aug 14. PubMed PMID: 26282994.

Yes

Deng A, Wang WH. Assessment of aneuploidy formation in human blastocysts resulting from cryopreserved donor eggs. Mol Cytogenet. 2015 Feb 15;8:12. doi: 10.1186/s13039-015-0117-8. eCollection 2015. PubMed PMID: 25713597; PubMed Central PMCID: PMC4339107. Open Access Article

No Esh-Broder E, Oron G, Son WY, Holzer H, Tulandi T. Early maternal serum ß-human chorionic gonadotropin (ß-hCG) levels and sex-related growth difference of IVF embryos. J Assist Reprod Genet. 2015 Oct;32(10):1491-5. doi: 10.1007/s10815-015-0550-y. Epub 2015 Aug 25. PubMed PMID: 26304101; PubMed Central PMCID: PMC4615924.
No Giménez C, Sarasa J, Arjona C, Vilamajó E, Martínez-Pasarell O, Wheeler K, Valls G, Garcia-Guixé E, Wells D. Karyomapping allows preimplantation genetic diagnosis of a de-novo deletion undetectable using conventional PGD technology. Reprod Biomed Online. 2015 Sep 8. pii: S1472-6483(15)00429-0. doi: 10.1016/j.rbmo.2015.08.017. [Epub ahead of print] PubMed PMID: 26507283. 
No Haddad G, Deng M, Wang CT, Witz C, Williams D, Griffith J, Skorupski J, Gill J, Wang WH. Assessment of aneuploidy formation in human blastocysts resulting from donated eggs and the necessity of the embryos for aneuploidy screening. J Assist Reprod Genet. 2015 May 9. [Epub ahead of print] PubMed PMID: 25956263 
Yes Lee YS, Park MJ, Park SH, Koo JS, Moon HS, Joo BS. Effect of laser-assisted multi-point zona thinning on development and hatching of cleavage embryos in mice. Clin Exp Reprod Med. 2015 Jun;42(2):51-57. Epub 2015 Jun 30. PubMed PMID: 26161333
No Liebermann J. Vitrification: A Simple and Successful Method for Cryostorage of Human Blastocysts. Cryopreservation and Freeze-Drying Protocols. Methods in Molecular Biology. Eds. Wolkers WF, Oldenhof HR. 2015. 1257: 305-319.
Yes Ruttanajit T, Chanchamroen S, Cram DS, Sawakwongpra K, Suksalak W, Leng X, Fan J, Wang L, Yao Y, Quangkananurug W. Detection and quantitation of chromosomal
mosaicism in human blastocysts using copy number variation sequencing. Prenat Diagn. 2015 Dec 16. doi: 10.1002/pd.4759. [Epub ahead of print] PubMed PMID:26676536. (LYKOS)
No Schiewe MC, Zozula S, Anderson RE, Fahy GM. Validation of microSecure vitrification (µS-VTF) for the effective cryopreservation of human embryos and oocytes. Cryobiology. 2015 Jul 23. pii: S0011-2240(15)00210-2. doi: 10.1016/j.cryobiol.2015.07.009. [Epub ahead of print] PubMed PMID: 26210008.
No Shimoda M, Iwayama H, Ishiyama M, Nakatani A, Yamashita M. Masanor Successful pregnancy by vitrified–warmed embryo transfer for a woman with Kallmann syndrome. J Reproductive Medicine and Biology. 2015 July 23. [Epub ahead of print] 2015-07-23
Yes Whitney JB, Anderson RE, Nugent N, Schiewe MC. Euploidy Predictability of Human Blastocyst Inner Cell Mass and Trophectoderm Grading. Annals of Clinical and Laboratory Research, 2015, Vol 3 No. 1:4.



Available? Reference
Yes Cao S, Zhao C, Zhang J, Wu X, Guo X, Ling X. Retrospective clinical analysis of two artificial shrinkage methods applied prior to blastocyst vitrification on the outcome of frozen embryo transfer. J Assist Reprod Genet. 2014 May;31(5):577-81. doi: 10.1007/s10815-014-0203-6. Epub 2014 Mar 9. PubMed PMID: 24610097; PubMed Central PMCID: PMC4016367
Yes Gliedt D, Goeters S, Saleh W. Embryo Rescue by Placement of Disassembled Day-3 Embryo in Empty Zona Pellucida (ZP) Results in Birth of Normal Female: Case Report. J Clin Embr. 2014 17(1):185-188. Open Access Article
No Guo H, Zhu P, Yan L, Li R, Hu B, Lian Y, Yan J, Ren X, Lin S, Li J, Jin X, Shi X, Liu P, Wang X, Wang W, Wei Y, Li X, Guo F, Wu X, Fan X, Yong J, Wen L, Xie SX, Tang F, Qiao J. The DNA methylation landscape of human early embryos. Nature. 2014 Jul 31;511(7511):606-10. doi: 10.1038/nature13544. Epub 2014 Jul 23. PubMed PMID: 25079557
No Heindryckx B, Neupane J, Vandewoestyne M, Christodoulou C, Jackers Y, Gerris J, Van den Abbeel E, Van Coster R, Deforce D, De Sutter P. Mutation-free baby born from a mitochondrial encephalopathy, lactic acidosis and stroke-like syndrome carrier after blastocyst trophectoderm preimplantation genetic diagnosis. Mitochondrion. 2014 Sep;18:12-7. doi: 10.1016/j.mito.2014.08.005. Epub 2014 Aug 23. PubMed PMID: 25159128
Yes Ishikawa T, Kyoya T, Nakamura Y, Sato E, Tomiyama T, Kyono K. Oxygen consumption rate of early pre-antral follicles from vitrified human ovarian cortical tissue. J Reprod Dev. 2014 Dec 27;60(6):460-7. doi: 10.1262/jrd.2014-009. Epub 2014 Sep 29. PubMed PMID: 25262776; PubMed Central PMCID: PMC4284321.Open Access Article
Yes Kroener LL, Ambartsumyan G, Pisarska MD, Briton-Jones C, Surrey M, Hill D. Increased blastomere number in cleavage-stage embryos is associated with higher aneuploidy. Fertil Steril. 2014 Dec 31. pii: S0015-0282(14)02514-X. doi: 10.1016/j.fertnstert.2014.12.090. [Epub ahead of print] PubMed PMID: 25557243.
No Neupane J, Vandewoestyne M, Heindryckx B, Ghimire S, Lu Y, Qian C, Lierman S, Van Coster R, Gerris J, Deroo T, Deforce D, De Sutter P. A systematic analysis of the suitability of preimplantation genetic diagnosis for mitochondrial diseases in a heteroplasmic mitochondrial mouse model. Hum Reprod. 2014 Feb 12. [Epub ahead of print] PubMed PMID: 24524987.
No Oron G, Sokal-Arnon T, Son WY, Demirtas E, Buckett W, Zeadna A, Holzer H, Tulandi T. Extended embryo culture is not associated with increased adverse obstetric or perinatal outcome. Am J Obstet Gynecol. 2014 Aug;211(2):165.e1-7. doi: 10.1016/j.ajog.2014.03.018. Epub 2014 Mar 12. PubMed PMID: 24631436
Yes Qi ST, Liang LF, Xian YX, Liu JQ, Wang W. Arrested human embryos are more likely to have abnormal chromosomes than developing embryos from women of advanced maternal age. J Ovarian Res. 2014 Jun 13;7:65. doi: 10.1186/1757-2215-7-65. eCollection 2014. PubMed PMID: 24955133; PubMed Central PMCID: PMC4065243. Open Access Article
Yes Tan Y, Yin X, Zhang S, Jiang H, Tan K, Li J, Xiong B, Gong F, Zhang C, Pan X, Chen F, Chen S, Gong C, Lu C, Luo K, Gu Y, Zhang X, Wang W, Xu X, Vajta G, Bolund L, Yang H, Lu G, Du Y, Lin G. Clinical outcome of preimplantation genetic diagnosis and screening using next generation sequencing. GigaScience 2014, 3:30 doi:10.1186/2047-217X-3-30. Published: 4 December 2014. Open Access Article
Yes Taylor TH, Patrick JL, Gitlin SA, Crain JL, Wilson JM, Griffin DK. Blastocyst euploidy and implantation rates in a young (<35 years) and old (≥35 years) presumed fertile and infertile patient population. Fertil Steril. 2014 Aug 22. pii: S0015-0282(14)01834-2. doi: 10.1016/j.fertnstert.2014.07.1207. [Epub ahead of print] PubMed PMID: 25154676.
No Taylor TH, Patrick JL, Gitlin SA, Wilson JM, Crain JL, Griffin DK. Comparison of aneuploidy, pregnancy and live birth rates between day 5 and day 6 blastocysts. Reprod Biomed Online. 2014 Sep;29(3):305-10. doi: 10.1016/j.rbmo.2014.06.001. Epub 2014 Jun 12. PubMed PMID: 25043891
No Taylor TH, Patrick JL, Gitlin SA, Wilson JM, Crain JL, Griffin DK. Outcomes of blastocysts biopsied and vitrified once versus those cryopreserved twice for euploid blastocyst transfer. Reprod Biomed Online. 2014 Jul;29(1):59-64. doi: 10.1016/j.rbmo.2014.03.001. Epub 2014 Mar 15. PubMed PMID: 24794643.
No Tobler KJ, Brezina PR, Benner AT, Du L, Xu X, Kearns WG. Two different microarray technologies for preimplantation genetic diagnosis and screening, due to reciprocal translocation imbalances, demonstrate equivalent euploidy and clinical pregnancy rates. J Assist Reprod Genet. 2014 Apr 26. [Epub ahead of print] PubMed PMID: 24771116.
No Wan CY, Song C, Diao LH, Li GG, Bao ZJ, Hu XD, Zhang HZ, Zeng Y. Laser-assisted hatching improves clinical outcomes of vitrified-warmed blastocysts developed from low-grade cleavage-stage embryos: a prospective randomized study. Reprod Biomed Online. 2014 May;28(5):582-9. doi: 10.1016/j.rbmo.2014.01.006. Epub 2014 Jan 27. PubMed PMID: 24631166
No Xiong B, Tan K, Tan YQ, Gong F, Zhang SP, Lu CF, Luo KL, Lu GX, Lin G. Using SNP array to identify aneuploidy and segmental imbalance in translocation carriers, Genomics Data, 2014 December, 2:92-95
No Yueping Zhang, Saijuan Zhu, Jialong Wu, Suying Liu, Xiaoxi Sun, Quadrivalent asymmetry in reciprocal translocation carriers predicts meiotic segregation patterns in cleavage stage embryos, Reproductive BioMedicine Online, Available online 8 July 2014, ISSN 1472-6483, http://dx.doi.org/10.1016/j.rbmo.2014.06.010.
No Zhang S, Tan K, Gong F, Gu Y, Tan Y, Lu C, Luo K, Lu G, Lin G. Blastocysts can be rebiopsied for preimplantation genetic diagnosis and screening. Fertil Steril. 2014 Dec;102(6):1641-5. doi: 10.1016/j.fertnstert.2014.09.018. Epub 2014 Oct 22. PubMed PMID: 25439805.
No Zhou H, Zao W, Zhang W, Shi J, Shi W. No adverse effects were identified on the perinatal outcomes after laser-assisted hatching treatment. Reprod Biomed Online. 2014 Dec;29(6):692-8. doi: 10.1016/j.rbmo.2014.08.011. Epub 2014 Sep 4. PubMed PMID: 25444502.

Available? Reference
No Dekel-Naftali M, Aviram-Goldring A, Litmanovitch T, Shamash J, Yonath H, Hourvitz A, Yung Y, Brengauz M, Schiff E, Rienstein S. Chromosomal integrity of human preimplantation embryos at different days post fertilization. J Assist Reprod Genet. 2013 Apr 18. [Epub ahead of print] PubMed PMID: 23595898
Yes Liang L, Wang CT, Sun X, Liu L, Li M, et al. (2013) Identification of Chromosomal Errors in Human Preimplantation Embryos with Oligonucleotide DNA Microarray. PLoS ONE 8(4): e61838. doi:10.1371/journal.pone.0061838. Open Access Article
No Sheikhi A, Jalali M, Gholamian M, Jafarzadeh A, Jannati S, Mousavifar N. Elimination of apoptotic spermatozoa by magnetic-activated cell sorting improves the fertilization rate of couples treated with ICSI procedure. Andrology. 2013 Oct 2. doi: 10.1111/j.2047-2927.2013.00140.x. [Epub ahead of print] PubMed PMID: 24123893
No Shi W, Zhang S, Zhao W, Xia X, Wang M, Wang H, Bai H, Shi J. Factors related to clinical pregnancy after vitrified-warmed embryo transfer: a retrospective and multivariate logistic regression analysis of 2313 transfer cycles. Hum Reprod. 2013 Apr 18. [Epub ahead of print] PubMed PMID: 23599130.
Yes Tan YQ, Tan K, Zhang SP, Gong F, Cheng DH, Xiong B, Lu CF, Tang XC, Luo KL, Lin G, Lu GX. Single-nucleotide polymorphism microarray-based preimplantation genetic diagnosis is likely to improve the clinical outcome for translocation carriers. Hum Reprod. 2013 Jul 11. [Epub ahead of print] PubMed PMID: 23847111.

Available? Reference
Yes Balakier H, Sojecki A, Motamedi G, Bashar S, Mandel R, Librach C. Is the zona pellucida thickness of human embryos influenced by women's age and hormonal levels? Fertil Steril. 2012 Jul;98(1):77-83. Epub 2012 May 17. PubMed PMID:22608315
Yes Fathi R, Valojerdi MR, Yazdi PE, Ebrahimi B, Alipour H, Hassani F. Development of 4-cell mouse embryos after re-vitrification. Cryobiology. 2012 Feb;64(1):23-6. Epub 2011 Nov 23. PubMed PMID: 22127305
No Hammoud I, Vialard F, Bergere M, Albert M, Gomes DM, Adler M, Malagrida L, Bailly M, Wainer R, Selva J. Follicular fluid protein content (FSH, LH, PG4, E2 and AMH) and polar body aneuploidy. J Assist Reprod Genet. 2012 Aug 14. [Epub ahead of print] PubMed PMID: 22890422.
Yes Hur YS, Park JH, Ryu EK, Yoon HJ, Yoon SH, Hur CY, Lee WD, Lim JH. Effect of artificial shrinkage on clinical outcome in fresh blastocyst transfer cycles. Clin Exp Reprod Med. 2011 Jun;38(2):87-92. Epub 2011 Jun 30. PubMed PMID: 22384424
No Karipcin FS, Moragianni VA, Milette B, Kinzer DR, Thornton KL, Barrett B, Penzias AS. Effect of steroid and antibiotic treatment during assisted hatching on IVF outcomes. Hum Fertil (Camb). 2012 Nov 28. [Epub ahead of print] PubMed PMID: 23190298
Yes Kroener L, Ambartsumyan G, Briton-Jones C, Dumesic D, Surrey M, Munné S, Hill D. The effect of timing of embryonic progression on chromosomal abnormality. Fertil Steril. 2012 Jul 11. [Epub ahead of print] PubMed PMID: 22789142
Yes Li L, Zhang X, Zhao L, Xia X, Wang W. Comparison of DNA apoptosis in mouse and human blastocysts after vitrification and slow freezing. Mol Reprod Dev. 2011 Dec 15. doi: 10.1002/mrd.22018. [Epub ahead of print] PubMed PMID: 22213487.
No Maman E, Geva LL, Yerushalmi G, Baum M, Dor J, Hourvitz A. ICSI increases ongoing pregnancy rates in patients with poor response cycle: multivariate analysis of 2819 cycles. Reproductive biomedicine online 17 September 2012 (Article in Press DOI: 10.1016/j.rbmo.2012.09.003)




Available? Reference
Yes Brezina P, Barker A, Benner A, Ross R, Nguyen KH, Anchan R, Richter K, Cutting G, Kearns W. Genetic normalization of differentiating aneuploid human embryos. Nature Precedings. Posted 23 June 2011. hdl:10101/npre.2011.6045.1
Yes Choi KH, Lee JH, Yang YH, Yoon TK, Lee DR, Lee WS. Efficiency of laser-assisted intracytoplasmic sperm injection in a human assisted reproductive techniques program. Clin Exp Reprod Med. 2011 Sep;38(3):148-152. Open Access Article
Yes Hur YS, Park JH, Ryu EK, Yoon HJ, Yoon SH, Hur CY, Lee WD, Lim JH. Effect of artificial shrinkage on clinical outcome in fresh blastocyst transfer cycles. Clin Exp Reprod Med. 2011 Jun;38(2):87-92. http://dx.doi.org/10.5653/cerm.2011.38.2.87 Open Access Article
Yes Iwayama H, Hochi S, Yamashita M. In vitro and in vivo viability of human blastocysts collapsed by laser pulse or osmotic shock prior to vitrification. J Assist Reprod Genet. 2011 Apr;28(4):355-61. doi: 10.1007/s10815-010-9522-4. Epub 2010 Dec 9. PubMed PMID: 21152966; PubMed Central PMCID: PMC3114962. Open Access Article
No Schoolcraft WB, Janzen JC. “Embryo biopsy: towards trophectoderm isolation and blastocyst analysis.” Human Assisted Reproductive Technology: Future Trends in Laboratory and Clinical Practice. Eds., David Gardner, Botros Rizk, Tommaso Falcone. Cambridge: Cambridge University Press, 2011. 260-268.
Yes Shahine LK, Milki AA, Westphal LM, Baker VL, Behr B, Lathi RB. Day 2 versus day 3 embryo transfer in poor responders: a prospective randomized trial. Fertil Steril. 2011 Jan;95(1):330-2. Epub 2010 Sep 1. PubMed PMID: 20813357
Yes Vandewoestyne M, Heindryckx B, Lepez T, Van Coster R, Gerris J, De Sutter P, Deforce D. Polar body mutation load analysis in a patient with A3243G tRNALeu(UUR) point mutation. Mitochondrion. 2011 Jul;11(4):626-9. Epub 2011 Apr 6. PubMed PMID: 21496500.
Yes Xu X, Duan X, Lu C, Lin G, Lu G. Dynamic distribution of NuMA and microtubules in human fetal fibroblasts, developing oocytes and somatic cell nuclear transferred embryos. Hum Reprod. 2011 Mar 15. [Epub ahead of print] PubMed PMID: 21406448. Open Access Article
Yes Zhu D, Zhang J, Cao S, Zhang J, Heng BC, Huang M, Ling X, Duan T, Tong GQ. Vitrified-warmed blastocyst transfer cycles yield higher pregnancy and implantation rates compared with fresh blastocyst transfer cycles-time for a new embryo transfer strategy? Fertil Steril. 2011 Apr;95(5):1691-5. PubMed PMID: 21315339

Available? Reference
Yes Brezina PR, Benner A, Rechitsky S, Kuliev A, Pomerantseva E, Pauling D, Kearns WG. Single-gene testing combined with single nucleotide polymorphism microarray preimplantation genetic diagnosis for aneuploidy: a novel approach in optimizing pregnancy outcome. Fertil Steril. 2010 Dec 6. [Epub ahead of print] PubMed PMID: 21144509.
Yes Christopikou D, Karamalegos C, Doriza S, Argyrou M, Sisi P, Davies S, Mastrominas M. Spindle and chromosome configurations of human oocytes matured in vitro in two different culture media. Reprod Biomed Online. 2010 May;20(5):639-48. Epub 2010 Feb 10. PubMed PMID: 20347392.
Yes Eaton JL, Hacker MR, Barrett CB, Thornton KL, Penzias AS. Influence of patient age on the association between euploidy and day-3 embryo morphology. Fertil Steril. 2010 Jun;94(1):365-7. Epub 2009 Dec 14. PubMed PMID: 20004892.
Yes Fiorentino F, Kokkali G, Biricik A, Stavrou D, Ismailoglu B, De Palma R, Arizzi L, Harton G, Sessa M, Pantos K. Polymerase chain reaction-based detection of chromosomal imbalances on embryos: the evolution of preimplantation genetic diagnosis for chromosomal translocations. Fertil Steril. Nov;94(6):2001-11, 2011, Epub 2010 Feb 18. PubMed PMID: 20171625.
Yes Fragouli E, Katz-Jaffe M, Alfarawati S, Stevens J, Colls P, Goodall NN, Tormasi S, Gutierrez-Mateo C, Prates R, Schoolcraft WB, Munne S, Wells D. Comprehensive chromosome screening of polar bodies and blastocysts from couples experiencing repeated implantation failure. Fertil Steril. 2010 Aug;94(3):875-87. Epub 2009 Jun 21. PubMed PMID: 19540479
Yes Galán A, Montaner D, Póo ME, Valbuena D, Ruiz V, Aguilar C, Dopazo J, Simón C. Functional genomics of 5- to 8-cell stage human embryos by blastomere single-cell cDNA analysis. PLoS One. 2010 Oct 26;5(10):e13615. PubMed PMID: 21049019; PubMed Central PMCID: PMC2964308. Open Access Article
Yes Hammoud I, Molina-Gomes D, Albert M, Bergere M, Bailly M, Wainer R, Selva J, Vialard F. Are zona pellucida laser drilling and polar body biopsy safe for in vitro matured oocytes? J Assist Reprod Genet. 2010 Jul;27(7):423-7. E pub 2010 May 22. PubMed PMID: 20495883. Open Access Article
Yes Jia Y, Hartshorn C, Hartung O, Wangh LJ. Heat shock memory in preimplantation mouse embryos. Fertil Steril. 2010 May 15;93(8):2760-3. Epub 2010 Apr 7. PubMed PMID: 20378108; PubMed Central PMCID: PMC2873134. Open Access Article
Yes Marquard KL, Stephens SM, Jungheim ES, Ratts VS, Odem RR, Lanzendorf S, Moley KH. Polycystic ovary syndrome and maternal obesity affect oocyte size in in vitro fertilization/intracytoplasmic sperm injection cycles. Fertil Steril. 2010 Nov 10. [Epub ahead of print] PubMed PMID: 21071018.
Yes Miyata H, Matsubayashi H, Fukutomi N, Matsuba J, Koizumi A, Tomiyama T. Relevance of the site of assisted hatching in thawed human blastocysts: a preliminary report. Fertil Steril. 2010 Nov;94(6):2444-7. Epub 2010 Feb 26. PubMed PMID: 20189555.
Yes Parks JC, McCallie BR, Janesch AM, Schoolcraft WB, Katz-Jaffe MG. Blastocyst gene expression correlates with implantation potential. Fertil Steril. 2010 Sep 21. [Epub ahead of print] PubMed PMID: 20864103.
Yes Schoolcraft WB, Fragouli E, Stevens J, Munne S, Katz-Jaffe MG, Wells D. Clinical application of comprehensive chromosomal screening at the blastocyst stage. Fertil Steril. 2010 Oct;94(5):1700-6. Epub 2009 Nov 25. PubMed PMID: 19939370
No Shu Y, Peng W, Zhang J. Pregnancy and live birth following the transfer of vitrified-warmed blastocysts derived from zona- and corona-cell-free oocytes. Reprod Biomed Online. 2010 Oct;21(4):527-32. Epub 2010 May 10. PubMed PMID: 20800550.
Yes Taei A, Gourabi H, Seifinejad A, Totonchi M, Shahbazi E, Valojerdi MR, Eftekhari P, Karimian L, Baharvand H. Derivation of new human embryonic stem cell lines from preimplantation genetic screening and diagnosis-analyzed embryos. In Vitro Cell Dev Biol Anim. 2010 Apr;46(3-4):395-402. Epub 2010 Feb 23. PubMed PMID: 20177993.
Yes Traversa MV, Carey L, Leigh D. A molecular strategy for routine preimplantation genetic diagnosis in both reciprocal and Robertsonian translocation carriers. Mol Hum Reprod. 2010 May;16(5):329-37. Epub 2010 Feb 19. PubMed PMID: 20172975. Open Access Article
Yes Valojerdi MR, Eftekhari-Yazdi P, Karimian L, Hassani F, Movaghar B. Effect of laser zona thinning on vitrified-warmed embryo transfer at the cleavage stage: a prospective, randomized study. Reprod Biomed Online. 2010 Feb;20(2):234-242. Epub 2009 Nov 18. PubMed PMID: 20113961.

Available? Reference
Yes Balakier H, Mandel R, Sojecki A, Motamedi G, Zaver S, Librach C. Laser zona thinning in women aged <or=37 years: a randomized study. Fertil Steril. 2009 Apr;91(4 Suppl):1479-82. Epub 2008 Sep 14. PubMed PMID: 18793768.
Yes Eaton JL, Hacker MR, Harris D, Thornton KL, Penzias AS. Assessment of day-3 morphology and euploidy for individual chromosomes in embryos that develop to the blastocyst stage. Fertil Steril. 2009 Jun;91(6):2432-6. Epub 2008 Apr 28. PubMed PMID: 18440522.
Yes Feng HL, Hershlag A, Scholl GM, Cohen MA. A retroprospective study comparing three different assisted hatching techniques. Fertil Steril. 2009 Apr;91(4 Suppl):1323-5. Epub 2008 Apr 3. PubMed PMID: 18394610.
Yes Hiraoka K, Hiraoka K, Horiuchi T, Kusuda T, Okano S, Kinutani M, Kinutani K. Impact of the size of zona pellucida thinning area on vitrified-warmed
cleavage-stage embryo transfers: a prospective, randomized study. J Assist Reprod Genet. 2009 Sep-Oct;26(9-10):515-21. Epub 2009 Oct 15. PubMed PMID: 19830543; PubMed Central PMCID: PMC2788686. Open Access Article
Yes Keskintepe L, Agca Y, Sher G, Keskintepe M, Maassarani G. High survival rate of metaphase II human oocytes after first polar body biopsy and vitrification: determining the effect of previtrification conditions. Fertil Steril. 2009 Nov;92(5):1706-15. Epub 2008 Oct 19. PubMed PMID: 18937944.
Yes Krieg SA, Lathi RB, Behr B, Westphal LM. Normal pregnancy after tetraploid karyotype on trophectoderm biopsy. Fertil Steril. 2009 Sep;92(3):1169.e9-1169.e10. Epub 2009 Jul 15. PubMed PMID: 9608167.
Yes Lathi RB, Behr B. Pregnancy after trophectoderm biopsy of frozen-thawed blastocyst. Fertil Steril. 2009 May;91(5):1938-40. Epub 2008 Apr 18. PubMed PMID: 18371958.
Yes Li J, Liu X, Wang H, Zhang S, Liu F, Wang X, Wang Y. Human embryos derived by somatic cell nuclear transfer using an alternative enucleation approach. Cloning Stem Cells. 2009 Mar;11(1):39-50. PubMed PMID: 19196043.
Yes Schoolcraft WB, Katz-Jaffe MG, Stevens J, Rawlins M, Munne S. Preimplantation aneuploidy testing for infertile patients of advanced maternal age: a randomized prospective trial. Fertil Steril. 2009 Jul;92(1):157-62. Epub 2008 Aug 9. PubMed PMID: 18692827
Yes Sertedaki A, Pantos K, Vrettou C, Kokkali G, Christofidou C, Kanavakis E, Dacou-Voutetakis C. Conception and pregnancy outcome in a patient with 11-bp deletion of the steroidogenic acute regulatory protein gene. Fertil Steril. 2009 Mar;91(3):934.e15-8. Epub 2008 Sep 30. PubMed PMID: 18829024.
Yes Sher G, Keskintepe L, Keskintepe M, Maassarani G, Tortoriello D, Brody S. Genetic analysis of human embryos by metaphase comparative genomic hybridization (mCGH) improves efficiency of IVF by increasing embryo implantation rate and reducing multiple pregnancies and spontaneous miscarriages. Fertil Steril. 2009 Dec;92(6):1886-94. Epub 2009 Jan 9. PubMed PMID: 19135663.
Yes Tucker MJ, Ball GD. Assisted hatching as a technique for use in human in vitro fertilization and embryo transfer is long overdue for careful and appropriate study. J Clin Embr. 2009;12:9–14.

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Yes Fathi R, Valojerdi MR, Eftekhari-Yazdi P. Effect of laser-assisted hatching and necrotic blastomere removal on the development of vitrified-warmed four-cell mouse embryos. J Assist Reprod Genet. 2008 Jul;25(7):333-9. Epub 2008 Aug 8. PubMed PMID: 18688708; PubMed Central PMCID: PMC2596673. Open Access Article
Yes Hiraoka K, Fuchiwaki M, Hiraoka K, Horiuchi T, Murakami T, Kinutani M, Kinutani K. Effect of the size of zona pellucida opening by laser assisted hatching on clinical outcome of frozen cleaved embryos that were cultured to blastocyst after thawing in women with multiple implantation failures of embryo transfer: a retrospective study. J Assist Reprod Genet. 2008 Apr;25(4):129-35. PubMed PMID: 18365308; PubMed Central PMCID: PMC2582072. Open Access Article
Yes Jones GM, Cram DS, Song B, Kokkali G, Pantos K, Trounson AO. Novel strategy with potential to identify developmentally competent IVF blastocysts. Hum Reprod. 2008 Aug;23(8):1748-59. Epub 2008 May 13. PubMed PMID: 18477572. Open Access Article
Yes Pangalos CG, Hagnefelt B, Kokkali G, Pantos K, Konialis CP. Birth of a healthy histocompatible sibling following preimplantation genetic diagnosis for chronic granulomatous disease at the blastocyst stage coupled to HLA typing. Fetal Diagn Ther. 2008;24(4):334-9. Epub 2008 Oct 8. PubMed PMID: 18841023.
Yes Turetsky T, Aizenman E, Gil Y, Weinberg N, Shufaro Y, Revel A, Laufer N, Simon A, Abeliovich D, Reubinoff BE. Laser-assisted derivation of human embryonic stem cell lines from IVF embryos after preimplantation genetic diagnosis. Hum Reprod. 2008 Jan;23(1):46-53. Epub 2007 Nov 7. PubMed PMID: 17989069. Open Access Article
Yes Valojerdi MR, Eftekhari-Yazdi P, Karimian L, Ashtiani SK. Effect of laser zona pellucida opening on clinical outcome of assisted reproduction technology in patients with advanced female age, recurrent implantation failure, or frozen-thawed embryos. Fertil Steril. 2008 Jul;90(1):84-91. Epub 2007 Sep 24. PubMed PMID: 17889864.
Yes Wang WH, Kaskar K, Gill J, DeSplinter T. A simplified technique for embryo biopsy for preimplantation genetic diagnosis. Fertil Steril. 2008 Aug;90(2):438-42. Epub 2007 Sep 19. PubMed PMID: 17880956.



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Yes Hiraoka K, Fuchiwaki M, Hiraoka K, Horiuchi T, Murakami T, Kinutani M, Kinutani K. Zona pellucida removal and vitrified blastocyst transfer outcome: a preliminary study. Reprod Biomed Online. 2007 Jul;15(1):68-75. PubMed PMID: 17623540.
Yes Kokkali G, Traeger-Synodinos J, Vrettou C, Stavrou D, Jones GM, Cram DS, Makrakis E, Trounson AO, Kanavakis E, Pantos K. Blastocyst biopsy versus cleavage stage biopsy and blastocyst transfer for preimplantation genetic diagnosis of beta-thalassaemia: a pilot study. Hum Reprod. 2007 May;22(5):1443-9. Epub 2007 Jan 29. PubMed PMID: 17261575. Open Access Article
Yes Konialis C, Hagnefelt B, Kokkali G, Pantos C, Pangalos C. Pregnancy following preimplantation genetic diagnosis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Prenat Diagn. 2007 Nov;27(11):1079-83. PubMed PMID: 17729386.
Yes Lanzendorf SE, Ratts VS, Moley KH, Goldstein JS, Dahan MH, Odem RR. A randomized, prospective study comparing laser-assisted hatching and assisted hatching using acidified medium. Fertil Steril. 2007 Jun;87(6):1450-7. Epub 2007 Jan 4. PubMed PMID: 17207801.
Yes Sagoskin AW, Levy MJ, Tucker MJ, Richter KS, Widra EA. Laser assisted hatching in good prognosis patients undergoing in vitro fertilization-embryo transfer: a randomized controlled trial. Fertil Steril. 2007 Feb;87(2):283-7. Epub 2006 Nov 13. PubMed PMID: 17094975.
Yes Tadir Y, Douglas-Hamilton DH. Laser effects in the manipulation of human eggs and embryos for in vitro fertilization. Methods Cell Biol. 2007;82:409-31. PubMed PMID: 17586266.




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Yes Balaban B, Urman B, Yakin K, Isiklar A. Laser-assisted hatching increases pregnancy and implantation rates in cryopreserved embryos that were allowed to cleave in vitro after thawing: a prospective randomized study. Hum Reprod. 2006 Aug;21(8):2136-40. Epub 2006 Apr 13. PubMed PMID: 16613888. Open Access Article
Yes  Hwu YM, Chen CP, Li SH, Chen PW, Lee RK, Fleming S. Expression of vascular endothelial growth factor messenger ribonucleic acid and protein in human preimplantation embryos. Fertil Steril. 2006 Jun;85(6):1830-2. Epub 2006 Apr 27. PubMed PMID: 16643910.
 Yes Jones AE, Wright G, Kort HI, Straub RJ, Nagy ZP. Comparison of laser-assisted hatching and acidified Tyrode's hatching by evaluation of blastocyst development rates in sibling embryos: a prospective randomized trial. Fertil Steril. 2006 Feb;85(2):487-91. PubMed PMID: 16595232.
 Yes Liebermann J, Tucker MJ. Comparison of vitrification and conventional cryopreservation of day 5 and day 6 blastocysts during clinical application. Fertil Steril. 2006 Jul;86(1):20-6. Epub 2006 Jun 8. PubMed PMID: 16762345.
 Yes Makrakis E, Angeli I, Agapitou K, Pappas K, Dafereras A, Pantos K. Laser versus mechanical assisted hatching: a prospective study of clinical outcomes. Fertil Steril. 2006 Dec;86(6):1596-600. Epub 2006 Oct 20. PubMed PMID: 17055494.
 Yes Mukaida T, Oka C, Goto T, Takahashi K. Artificial shrinkage of blastocoeles using either a micro-needle or a laser pulse prior to the cooling steps of vitrification improves survival rate and pregnancy outcome of vitrified human blastocysts. Hum Reprod. 2006 Dec;21(12):3246-52. Epub 2006 Aug 26. PubMed PMID: 16936299. Open Access Article
 Yes Richter KS, Davis A, Carter J, Greenhouse SJ, Mottla GL, Tucker MJ. No advantage of laser-assisted over conventional intracytoplasmic sperm injection: a randomized controlled trial [NCT00114725]. J Exp Clin Assist Reprod. 2006 Jul 5;3:5. PubMed PMID: 16822317; PubMed Central PMCID: PMC1550249. Open Access Article
 Yes Vialard F, Petit C, Bergere M, Gomes DM, Martel-Petit V, Lombroso R, Ville Y, Gerard H, Selva J. Evidence of a high proportion of premature unbalanced separation of sister chromatids in the first polar bodies of women of advanced age. Hum Reprod. 2006 May;21(5):1172-8. Epub 2006 Jan 12. PubMed PMID: 16410329. Open Access Article

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Yes Hartshorn C, Anshelevich A, Wangh LJ. Laser zona drilling does not induce hsp70i transcription in blastomeres of eight-cell mouse embryos. Fertil Steril. 2005 Nov;84(5):1547-50. PubMed PMID: 16275269.
Yes Hartshorn C, Anshelevich A, Wangh LJ. Rapid, single-tube method for quantitative preparation and analysis of RNA and DNA in samples as small as one cell. BMC Biotechnol. 2005 Jan 13;5:2. PubMed PMID: 15649321; PubMed Central PMCID: PMC546192. Open Access Article
 Yes Kokkali G, Vrettou C, Traeger-Synodinos J, Jones GM, Cram DS, Stavrou D, Trounson AO, Kanavakis E, Pantos K. Birth of a healthy infant following trophectoderm biopsy from blastocysts for PGD of beta-thalassaemia major. Hum Reprod. 2005 Jul;20(7):1855-9. Epub 2005 May 5. PubMed PMID: 15878929. Open Access Article
 Yes McArthur SJ, Leigh D, Marshall JT, de Boer KA, Jansen RP. Pregnancies and live births after trophectoderm biopsy and preimplantation genetic testing of human blastocysts. Fertil Steril. 2005 Dec;84(6):1628-36. PubMed PMID: 16359956.
 Yes Nagy ZP, Taylor T, Elliott T, Massey JB, Kort HI, Shapiro DB. Removal of lysed blastomeres from frozen-thawed embryos improves implantation and pregnancy rates in frozen embryo transfer cycles. Fertil Steril. 2005 Dec;84(6):1606-12. PubMed PMID: 16359953.
Yes Tinney GM, Windt ML, Kruger TF, Lombard CJ. Use of a zona laser treatment system in assisted hatching: optimal laser utilization parameters. Fertil Steril. 2005 Dec;84(6):1737-41. PubMed PMID: 16359974.

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Yes Miller KA, Elkind-Hirsch K, Levy B, Graubert MD, Ross SJ, Scott RT Jr. Pregnancy after cryopreservation of donor oocytes and preimplantation genetic diagnosis of embryos in a patient with ovarian failure. Fertil Steril. 2004 Jul;82(1):211-4. PubMed PMID: 15237014.

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Yes Han TS, Sagoskin AW, Graham JR, Tucker MJ, Liebermann J. Laser-assisted human embryo biopsy on the third day of development for preimplantation genetic diagnosis: two successful case reports. Fertil Steril. 2003 Aug;80(2):453-5. PubMed PMID: 12909515.
Yes Wong BC, Boyd CA, Lanzendorf SE. Randomized controlled study of human zona pellucida dissection using the zona infrared laser optical system: evaluation of blastomere damage, embryo development, and subsequent hatching. Fertil Steril. 2003 Nov;80(5):1249-54. PubMed PMID: 14607583.

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Yes Balaban B, Urman B, Alatas C, Mercan R, Mumcu A, Isiklar A. A comparison of four different techniques of assisted hatching. Hum Reprod. 2002 May;17(5):1239-43. PubMed PMID: 11980745. Open Access Article

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Yes Douglas-Hamilton DH, Conia J. Thermal effects in laser-assisted pre-embryo zona drilling. J Biomed Opt. 2001 Apr;6(2):205-13. PubMed PMID: 11375731.
Yes Douglas-Hamilton DH, Conia JD. Laser-assisted technique aims to improve infertility measures. Biophotonics Int. Sep/Oct 2001

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Yes Douglas-Hamilton DH, Conia JD. Thermal effects in laser-assisted embryo hatching. Proc. SPIE 4065, 260 (2000); doi:10.1117/12.407338