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ZILOS-tk

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Caution: Federal law restricts this device to sale by or on the order of a physician or a practitioner trained and certified in its use. Assisted Hatchling, Embryo Biopsy and PGD are not recommended for routine use in all IVF patients.
Please Note: For animal research and human stem cell applications, the XYClone® should be used.

ZILOS-tk® for Clinical Laser-assisted Hatching (LAH)

The advent of the laser has allowed the development of precision techniques to manipulate embryos for enhanced fertility. Laser-assisted hatching can turn around a history of failure for embryos to implant themselves in the uterine wall.

Assisted hatching is used to help the embryo hatch from its protective outer shell, the zona pellucida, and promote implantation in the uterine wall after embryo transfer. Laser-assisted hatching (LAH) with the ZILOS-tk® uses a highly focused infrared laser beam to remove the zona pellucida in very precise increments. Prior to the clinical availability of the ZILOS-tk®, only mechanical or chemical methods could be used for assisted hatching of human embryos in clinical settings. Laser-assisted hatching requires less handling of the embryo than these other assisted hatching methods. Also, laser-assisted hatching is faster than the other methods and, therefore, the embryo spends less time outside the incubator.


Image courtesy of Stephen Harbottle

View Laser Assisted Hatching Video

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Indications for LAH

LAH is not recommended for routine use in all IVF patients, and several factors should be considered in determining candidates for LAH. These include age, hormonal status, embryo quality, # of IVF attempts, and whether frozen embryos are being implanted.

Age Women over 37 years old
Hormonal Status Women with an elevated baseline level of FSH (follicular stimulating hormone)
Embryo Quality Women with poor prognosis embryos, including conditions such as a thick zona pellucida, slow cell division rate, or high cell fragmentation
IVF Attempts Women who have failed 1 or more IVF cycles
Frozen Embryos Women using frozen/thawed embryos, which may have hardened zona pellucida
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