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XYClone is for non-clinical research use only in USA. hESC research using the XYClone should be conducted in accordance with any applicable Federal, State or local laws and regulations.
Please Note: The XYClone™ is for use ONLY with ANIMAL and STEM CELL APPLICATIONS. (For Clinical Laser Assisted Hatching and Biopsy applications, please see the ZILOS-tk.)
XYClone for Developmental Biology - Selective Laser Ablation
Our early adopter for using the XYClone laser for selective cell ablation is Dr. Jon Henry, Professor and Associate Head of the Department of Cell and Developmental Biology at the University of Illinois at Urbana-Champaign campus. His studies focus on regeneration of cells, particulary mechanisms of lens development and regeneration. Although his emphasis has been in studies of Xenopus laevis (frog), Dr. Henry also studies Crepidula fornicata (slipper snail mollusk), Ophryotrocha labronica (marine polyclaete annelid), planarians (flatworms), to name a few. His intention is to use the XYClone laser system to ablate cells during development, ablate the eye/eye parts to study regeneration, ablate other structures in the animal to distrupt function and study compensation/regeneration.
All photos below are courtesy Dr. Jon Henry.
Before and after laser ablation of planarian photoreceptors
Before and after laser ablation of slipper snail daughter cell (micromere)
Before and after laser ablation of C. elegans egg cell
Crepidula fornicata: Successive stages in the death of the 4d mesentoblast cell following laser ablation
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