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LYKOS

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Laser Objective with RED-i Target Locator

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Caution: For US CLinical Use: Federal law restricts this device to sale by or on the order of a physician or a practitioner trained and certified in its use. Assisted Hatching, Embryo Biopsy and PGD are not recommended for routine use in all IVF patients.

LYKOS™ for Clinical Laser-assisted Embryo Biopsy (LAB)

Laser-assisted biopsy is used to facilitate removal of cells from an embryo for pre-implantation genetic diagnosis (PGD) testing. There are two current methods used for embryo biopsy: blastomere biopsy and trophectoderm biopsy.

Blastomere Biopsy

Blastomere biopsy, the most common method of embryo biopsy, involves the removal of one or two blastomeres when the embryo reaches the eight-cell stage, typically at the third day of development.

Blastomere Biopsy
Image courtesy of Stephen Harbottle

View / Download above Blastomere Biopsy Video as WMV

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Trophectoderm Biopsy

Recently, trophectoderm biopsy is gaining popularity as an alternative method of embryo biopsy. Since trophectoderm cells are extra-embryonic tissue, they do not become part of the fetus but do become part of supporting structures, such as the placenta and membranes. Trophectoderm biopsy takes place at the 16-32 cell “blastocyst” stage of development, as the trophectoderm is beginning to herniate through the zona pellucida. Instead of removing individual blastomeres, several trophectoderm cells are removed.

Trophectoderm Biopsy

View / Download above Trophectoderm Biopsy Video as WMV

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Polar Body Biopsy

View / Download above Polar Body Biopsy Video as WMV

Indications for Laser-assisted Embryo Biopsy

LAB is not recommended for routine use in all IVF patients, and several factors should be considered in determining candidates for LAB. These include the following:

Carriers of Single Gene Disorders These patients benefit from PGD by reducing the risk of conceiving an affected baby
Recurrent Miscarriage Fertile couples with repeated miscarriages should be evaluated for the presence of a chromosomal abnormality. The female or male partner may be a carrier of a balanced translocation or be an aneuploid mosaic
Unsuccessful IVF Cycles Couples with repeated unsuccessful IVF cycles should be evaluated for the presence of a chromosome abnormality. The female or male partner may be a carrier of a balanced translocation or be an aneuploid mosaic
Unexplained Infertility The most probable cause of unexplained infertility or history of habitual miscarriage is a chromosome abnormality. The male OR female partner may be a carrier of a translocation or be an aneuploid mosaic
Aneuploidy or Advanced maternal Age Women of advanced maternal age (> 35) are at a higher risk of producing aneuploid embryos, resulting in implantation failure, a higher risk of miscarriage or the birth of a child with a chromosome abnormality (e.g. Down syndrome)

 

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