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TOX IVOS Computer Assisted Sperm Analyzer
About the TOX IVOS
Uniquely Suited to Be Your Laboratory PartnerThe TOX IVOS Sperm Analyzer has unique features that increase laboratory efficiency and ease of use without sacrificing analysis accuracy. From its integrated optical system to its real-time "prove it" ability of the Playback function, the TOX IVOS works with you to provide fast, user-friendly analysis and accurate, validated results. Return to Top21CFR11 Compliance and GLP ValidationWith the addition of new security and electronic records features in Version 12.1, the TOX IVOS is now fully compliant with 21CFR11. Specifically developed to comply with regulatory guidelines, the TOX IVOS is supported by full documentation. Our TOX IVOS Validation Handbook outlines specific GLP protocols to verify the accuracy of internal calculations. The TOX IVOS analyzer has been validated by governmental, pharmaceutical and commercial reproductive toxicology labs. Please call for a list of installed sites. For more information, view the 21CFR11 Information Sheet and 21CFR11 Compliance Statement. (PDF file). Return to TopCustomized Algorithms for Rat Sperm AnalysisBecause of the large size of the rat sperm and the unique shape of its head, customized algorithms have been developed for rat sperm analysis with the TOX IVOS. Using these special algorithms, the TOX IVOS digitally "separates" the sperm head from the midpiece. The TOX IVOS is able to isolate the sperm head in this method because it is the only sperm analyzer that uses the whole sperm image, not just the border, for analysis. The precise identification and tracking of sperm can be immediately confirmed with the full-disclosure Playback feature of the TOX IVOS. Return to TopAccurate Total Sperm Counts in Homogenized TissueThe time-consuming task of hemacytometer sperm counts is now a thing of the past. For total sperm counts in homogenized tissue, nothing matches the ease of use and accuracy of the IDENT fluorescing system. Integrated into the TOX IVOS, the IDENT fluorescent illumination is activated at the touch of a button. Sample preparation for the IDENT analysis requires a simple three minute staining procedure. Since the IDENT stain is DNA-specific, sperm heads are clearly illuminated and identified while debris is ignored. As with standard analysis, accurate identification is immediately confirmed with the Playback feature. Return to TopAutomatic Storage of Digital Images to Optical DiskFor compliance with regulatory guidelines, raw data of all fields analyzed may be automatically saved to optical disk with the Digital Image Storage Option. Because the exact sperm images are saved to disk, digital image storage is the optimum QC method. If preferred, images may also be easily recorded to videotape. For easy retrieval from optical disk, the analysis setup, the study name and the animal number are stored with each image file. Each optical disk stores over a gigabyte of data - enough space to archive a complete study. With the 30 year, guaranteed lifetime of an optical disk, digital image storage of analysis fields satisfies the most stringent QC requirements. Return to TopProfessional Training and Ongoing SupportProfessional installation and two days of user training are included with every TOX IVOS system. A step-by-step training checklist ensures that all installed options are explained in detail and understood in full. Hamilton Thorne Research also offers free, on-line technical and application support via our toll free number, fax and e-mail. Return to TopWhat the TOX IVOS System IncludesThe TOX IVOS System is a comprehensive system, which, in addition to the standard motility software, includes all the following options:
Return to TopSummary of Sperm Analysis Results Provided
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The TOX IVOS system for sperm analysis has been validated in governmental, commercial and pharmaceutical reproductive toxicology laboratories around the world. With the new EU REACH framework soon to be enforced, the TOX IVOS can help companies with compliance studies.